Clinical study on Anshen Bunao Liquid combined with diazepam in treatment of insomnia with qi and blood deficiency type
Objective To explore the therapeutic effect of Anshen Bunao Liquid combined with diazepam in treatment of insomnia with qi and blood deficiency type.Methods Patients(112 cases)with insomnia with qi and blood deficiency type in Liaocheng Second People's Hospital from June 2022 to June 2023 were divided into control and treatment group based on different treatments,and each group had 56 cases.Patients in the control group were po administered with Diazepam Tablets,5 mg/time,twice daily.Patients in the treatment group were po administered with Anshen Bunao Liquid on the basis of the control group,10 mL/time,twice daily.Patients in two groups were treated for 4 weeks.After treatment,the clinical evaluations were evaluated,the insomnia,fatigue,and quality of life,the levels of serum 5-HT,BDNF and GABA,and the serum pro-inflammatory and anti-inflammatory cytokine levels in two groups before and after treatment were compared.Results After treatment,the total clinical effective rate of the control group and the treatment group was 78.57%and 94.64%respectively,and the difference between two groups was statistically significant(P<0.05).After treatment,the ISI and MFI-20 scores in two groups were significantly decreased,while the WHOQOL-BREF scores were significantly increased,and these scores in the treatment group were improved more significantly(P<0.05).After treatment,the levels of serum 5-HT,BDNF,GABA,THF-α and IL-1β in two groups were significantly increased,while the levels of IL-4 and IL-10 were significantly decreased,and the level of serology in the treatment group was significantly better than that in the control group(P<0.05).Conclusion The combination of Anshen Bunao Liquid and diazepam has a significant therapeutic effect on insomnia of qi and blood deficiency type,which can not only significantly improve the degree of fatigue and quality of life,but also promote the recovery of serological indexes and effectively improve the balance of inflammatory factors.
Anshen Bunao LiquidDiazepam Tabletsqi and blood deficiencyinsomnia5-HTBDNFGABA
NETL
NSTL
万方数据
