Clinical study of Xintong Oral Liquid combined with aspirin in treatment of angina pectoris of coronary heart disease
Objective To explore the clinical efficacy of Xintong Oral Liquid combined with aspirin in treatment of angina pectoris of coronary heart disease.Methods 116 Patients with angina pectoris of coronary heart disease admitted to Beijing Friendship Hospital from March 2021 to March 2022 were selected and divided into control group and treatment group according to random number table method,with 58 patients in each group.Patients in the control group were po administered with Aspirin Enteric-coated Tablets,1 tablet/time,once daily.Patients in the treatment group were po administered with Xintong Oral Liquid on the basis of the control group,10 mL/time,three times daily.The treatment course of both groups was 4 weeks.The clinical efficacy of two groups was observed.After treatment,angina pectoris attack,coagulation function index[D-dimer(D-D),fibrinogen(FIB),prothrombin time(PT)]and inflammation index[C-reactive protein(CRP),platelet-lymphocyte ratio(PLR),neutrophil to lymphocyte ratio(NLR)]were compared between two groups before and after treatment.The adverse reactions of the two groups were analyzed.Results After treatment,the total effective rates of angina pectoris and electrocardiogram in treatment group were 94.83%and 89.66%,respectively,which were significantly higher than 82.76%and 75.86%in control group(P<0.05).After treatment,the frequency of angina pectoris attack,the amount of nitroglycerin and the duration of angina pectoris in both groups were significantly decreased(P<0.05).After treatment,the condition control of treatment group was better than that of control group(P<0.05).After treatment,plasma D-D and FIB levels were significantly decreased,but PT was significantly prolonged in both groups(P<0.05).After treatment,the improvement of coagulation function index in treatment group was better than that in control group(P<0.05).After treatment,PLR,NLR and CRP in 2 groups were significantly decreased compared with before treatment(P<0.05).After treatment,the inflammation-related indexes in treatment group were lower than those in control group(P<0.05).After treatment,the incidence of adverse reactions in the treatment group and the control group was 8.62%and 6.90%,respectively,and there was no statistical significance between the two groups.Conclusion Xintong Oral Liquid combined with aspirin has a significant overall therapeutic effect in treatment of angina pectoris of coronary heart disease,and can significantly improve the coagulation function of the body,inhibit the inflammatory state of the body,and effectively control the attack of angina pectoris,which is worthy of clinical application.
Xintong Oral LiquidAspirin Enteric-coated Tabletsangina pectoris of coronary heart diseaseD-DFIBPTCRPPLRNLR
NETL
NSTL
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