Clinical study on dapagliflozin combined with pravastatin in treatment of chronic heart failure
Objective To investigate the clinical efficacy of Dapagliflozin Tablets combined with Pravastatin Sodium Tablets in treatment of chronic heart failure.Methods Patients(114 cases)with chronic heart failure in Xingtai Central Hospital from February 2022 to December 2023 were divided into control and treatment groups according to the random number method,and each group had 72 cases.Patients in the control group were po administered with Pravastatin Sodium Tablets,2 tablets/time,once daily.Patients in the treatment group were po administered with Dapagliflozin Tablets on the basis of the control group,1 tablets/time,once daily.Patients in two groups were treated for 2 months.The clinical efficacies,the degree of illness,the quality of life,the heart function,and the serum indicators in two groups were compared.Results After treatment,the total effective rate of the treatment group was 94.44%,which was higher than 83.33%of the control group,and the difference between groups was significant(P<0.05).After treatment,the heart failure score and MLHFQ score of two groups were significantly decreased(P<0.05),and the scores of heart failure and MLHFQ in the treatment group were lower than those in the control group(P<0.05).After treatment,EF in two groups was significantly increased,but LVRI and LVMI in two groups were significantly decreased(P<0.05).After treatment,EF in treatment group was higher than that in control group,but LVRI and LVMI in treatment group were lower than that in control group(P<0.05).After treatment,the serum levels of NT-proBNP,RBP4,and ADP in two groups were significantly decreased(P<0.05).Compared with the control group,the serum levels of NT-proBNP,RBP4,and ADP in the treatment group were lower(P<0.05).Conclusion Dapagliflozin Tablets combined with Pravastatin Sodium Tablets can significantly reduce the severity of chronic heart failure,improve the quality of life and cardiac function of patients,and reduce myocardial damage.
NETL
NSTL
万方数据
