Clinical study on sulfotanshinone sodium combined with arotinolol in treatment of unstable angina pectoris
Objective To explore the effectiveness of sulfotanshinone sodium combined with arotinolol in treatment of unstable angina pectoris.Methods Patients(185 cases)with unstable angina pectoris in Wuhan Hospital of Traditional Chinese Medicine from March 2022 to March 2023 were divided into control(93 cases)and treatment(92 cases)group based on different treatments.Patients in the control group were po administered with Arotinolol Hydrochloride Tablets,1 tablet/time,twice daily.Patients in the treatment group were iv administered with Sulfotanshinone Sodium Injection on the basis of the control group,40 mg added into normal saline 100 mL,once daily.Patients in two groups were treated for 2 weeks.After treatment,the clinical evaluations were evaluated,the cardiac function related indicators LVEF,LVESD and 6 min walking distance,the levels of serum sST2,cTnⅠ,MCP-1,LTBP-2 and VASP,and the scores of VAS and GQOLI-74 in two groups before and after treatment were compared.Results After treatment,the clinical effective rates of the control group and the treatment group were 82.80%and 97.83%respectively,and the difference between the two groups was statistically significant(P<0.05).After treatment,the indexes of LVEF and 6 min walking distance were significantly increased,while LVESD was significantly decreased in two groups(P<0.05),and the related indexes of cardiac function were improved more significantly in the treatment group(P<0.05).After treatment,the serum levels of sST2,cTnⅠ,MCP-1 and LTBP-2 were significantly decreased,while the level of VASP was significantly increased in two groups(P<0.05),and the improvement of each index in the treatment group was more obvious(P<0.05).After treatment,the VAS score of angina pectoris was significantly decreased,while the GQOLI-74 score was significantly increased in two groups(P<0.05),and the improvement was more obvious in the treatment group(P<0.05).Conclusion Sulfotanshinone Sodium Injection combined with aroprolol has significant therapeutic effects on unstable angina pectoris,which can not only significantly improve the cardiac function and promote the recovery of serological indexes,but also improve the quality of life of patients.
Sulfotanshinone Sodium InjectionArotinolol Hydrochloride Tabletsunstable angina pectorisLVESDLVEF6 min walking distancecTnⅠVASPVASGQOLI-74
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