Clinical study on Jinshuibao Tablets combined with and ipratropium bromide in treatment of chronic bronchitis
Objective To explore the clinical efficacy of Jinshuibao Tablets combined with and ipratropium bromide in treatment of chronic bronchitis.Methods Patients(106 cases)with chronic bronchitis in the Affiliated Hospital of Inner Mongolia Medical University from January 2021 to November 2023 were randomly divided into control(53 cases)and treatment(53 cases)group.Patients in the control group were atomization inhalation administered with Ipratropium Bromide Solution for Inhalation,2 mL/time,twice daily.Patients in the treatment group were po administered with Jinshuibao Tablets on the basis of the control group,4 tablets/time,three times daily.Patients in two groups were treated for 3 months.After treatment,the clinical evaluations were evaluated,the disappearance time of main symptoms,lung function indicators FVC,PEF and MMEF,T lymphocyte subsets levels of peripheral blood,and the levels of serum Eotaxin,TNF-α,TGF-β1 and ET-1 in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 96.23%,which was significantly higher than that of the control group(84.91%,P<0.05).After treatment,the disappearance time of the main symptoms in the treatment group was significantly shorter than that in the control group(P<0.05).After treatment,the levels of FVC,PEF,MMEF,CD3+,CD4+and CD4+/CD8+in two groups were significantly higher than those before treatment,while the levels of CD8+,Eotaxin,TNF-α,TGF-β1 and ET-1 were significantly lower than those before treatment(P<0.05),and the pulmonary function indexes,peripheral blood T lymphocyte subsets and serum factor levels in the treatment group were significantly better than those in the control group(P<0.05).Conclusion Jinshuibao Tablets combined with ipratropium bromide in treatment of chronic bronchitis can accelerate the relief of symptoms,improve lung function and clinical efficacy and immune function and inflammatory state.
Jinshuibao TabletsIpratropium Bromide Solution for Inhalationchronic bronchitisFVCPEFMMEFTlymphocyte subpopulationsEotaxinendothelin-1
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