Clinical study of Allitride Injection combined with imipenem and cilastatin sodium in treatment of severe community-acquired bacterial pneumonia
Objective To investigate the therapeutic effect of Allitride Injection combined with imipenem and cilastatin sodium in treatment of severe community-acquired bacterial pneumonia.Methods Eighty patients with severe community-acquired bacterial pneumonia admitted to Jiamusi Hospital of Traditional Chinese Medicine and Jiamusi Central Hospital from October 2020 to October 2023 were selected and divided into control group and treatment group according to drug usage,with 40 cases in each group.Patients in control group were iv administered with Imipenem and Cilastatin Sodium for injection,0.5 g was diluted into 0.9%sodium chloride100 mL,twice daily.Patients in treatment group were iv administered with Allitride Injection on the basis of control group,90 mg was diluted with 0.9%sodium chloride 500 mL,once daily.The two groups were treated continuously for 10 d.The clinical efficacy and symptom improvement time of two groups were observed,and the changes of Murray Lung Injury score(MLIS),Pulmonary Infection Scale(CPIS)score,serum procalcitonin(PCT),high mobility group protein B1(HMGB1),interleukin-1β(IL-1β),soluble intercellular adhesion molecule-1(sICAM-1),forced expiratory volume in the first second(FEV1),forced vital capacity(FVC),and the percentage of forced expiratory volume in forced vital capacity in the first second(FEV1/FVC%)in two groups before and after treatment were compared.Results After treatment,the total effective rate of the treatment group was 95.00%,which was significantly higher than that of the control group(77.50%,P<0.05).After treatment,the improvement time of wheezing,hypoxia,cough and pulmonary rales in treatment group was significantly shorter than that in control group(P<0.05).After treatment,MLIS score and CPIS score in 2 groups were significantly lower than before treatment(P<0.05).After treatment,MLIS score and CPIS score in treatment group were lower than those in control group(P<0.05).After treatment,the serum levels of PCT,HMGB1,IL-1β and sICAM-1 in 2 groups were significantly decreased(P<0.05).After treatment,the levels of PCT,HMGB1,IL-1β and sICAM-1 in treatment group were lower than those in control group(P<0.05).After treatment,the levels of FEV1,FVC and FEV1/FVC in 2 groups were significantly higher than before treatment(P<0.05).After treatment,the levels of FEV1,FVC and FEV1/FVC in treatment group were higher than those in control group(P<0.05).Conclusion Allitride Injection combined with imipenem and cilastatin sodium has good clinical efficacy in treatment of severe community-acquired bacterial pneumonia,and can alleviate the clinical symptoms of patients,also can reduce the inflammatory factors,which is worthy of reference and application.
Allitride InjectionImipenem and Cilastatin Sodium for injectionsevere community-acquired bacterial pneumoniasymptom recovery timeMLIS scoreCPIS scorePCTHMGB1FEV1FVC
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