Clinical study on Shuanghuanglian Oral Liquid combined with oseltamivir in treatment of acute upper respiratory tract infection in children
Objective To investigate the clinical effect of Shuanghuanglian Oral Liquid combined with Oseltamivir Phosphate Granules in treatment of acute upper respiratory tract infection in children.Methods Children(104 cases)with acute upper respiratory tract infection in Shanghai Fengxian District Central Hospital from July 2021 to June 2023 were divided into control and treatment groups according to the computer random arrangement method,and each group had 52 cases.Children in the control group were po administered with Oseltamivir Phosphate Granules,with a body mass≤15,>15—23,>23—40,and>40 kg with dosage of 30,45,60,and 75 mg/time,twice daily.Children in the treatment group were po administered with Shuanghuanglian Oral Liquid on the basis of the control group,3 mL/time under 3 years old,5 mL/time between 3—5 years old,and 10 mL/time between 5 years old and above,three times daily.Children in two groups were treated for 5 d.The clinical efficacies,symptom disappearance time,and serum indicators in two groups were compared.Results The total effective rate of the treatment group was 96.15%,which was higher than 84.62%of the control group,and the difference was statistically significant(P<0.05).Fever relief time,cough relief time,phlegm disappearance time,and runny nose disappearance time in the treatment group were shorter than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the serum levels of SAA,IL-18,IL-4,and TRAIL in two groups were lower than before treatment(P<0.05),and the serum levels of SAA,IL-18,IL-4 and TRAIL in the treatment group were lower than those in the control group(P<0.05).Conclusion Shuanghuanglian Oral Liquid combined with Oseltamivir Phosphate Granules is effective in the treatment of children with acute upper respiratory tract infection,which can improve the efficiency of symptom improvement,further reduce inflammation.
Shuanghuanglian Oral LiquidOseltamivir Phosphate Granulesacute upper respiratory tract infection in childrenfever relief timecough relief timephlegm disappearance timerunny nose disappearance timeSAAIL-18IL-4TRAIL
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