Clinical study on Xuebijing Injection combined with dexamethasone in treatment of severe sepsis
Objective To explore the therapeutic effect of Xuebijing Injection combined with Dexamethasone Sodium Phosphate Injection in treatment of severe sepsis.Methods Patients(66 cases)with severe sepsis in Chongqing University Fuling Hospital from January to December 2023 were divided into control and treatment groups according to different medication plans,and each group had 33 cases.Patients in the control group were iv administered with Dexamethasone Sodium Phosphate Injection,10 mg added into 5％glucose solution 250 mL,once daily.Patients in the treatment group were iv administered with Xuebijing Injection on the basis of the control group,100 mL added into 5％glucose solution 250 mL,twice daily.Patients in two groups were treated for 1 week.The clinical efficacies,clinical symptom improvement time,disease severity,and inflammatory factors serum levels in two groups were compared.Results After treatment,the total effective rate of the treatment group was 90.91％,which was higher than 63.64％of the control group(P<0.05).After treatment,the recovery time,blood pressure normalization time,and body temperature recovery time of the treatment group were shorter than those of the control group(P<0.05).After treatment,APACHE Ⅱ scores of two groups were lower than those before treatment(P<0.05),and APACHE Ⅱ scores of the treatment group were lower than those of the control group(P<0.05).After treatment,the serum levels of CRP,IL-6,and TNF-α in two groups were decreased(P<0.05),and the serum levels of CRP,IL-6,and TNF-α in treatment group were lower than those in control group(P<0.05).Conclusion Xuebijing Injection combined with Dexamethasone Sodium Phosphate Injection in treatment of severe sepsis has a significant therapeutic effect,can shorten the time for clinical symptom improvement,reduce the severity of patients'disease and the level of inflammation.
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