Clinical observation of Compound Yimucao Capsules combined with norethisterone in treatment of menstrual irregularities
Objective To explore the clinical application value of Compound Yimucao Capsules combined with norethisterone in treatment of menstrual irregularities.Methods Patients(88 cases)with menstrual irregularities in Cangzhou Hospital of Integrated TCM-WM Hebei from January 2021 to June 2023 were randomly divided into control(44 cases)and treatment(44 cases)group.Patients in the control group were po administered with Norethisterone Tablets from the fifth day of the menstrual cycle,3.75 mg/time,twice daily.Patients in the treatment group were po administered with Compound Yimucao Capsules on the basis of the control group from the second day of the menstrual cycle,5 grains/time,twice daily.Patients in two groups were treated for two menstrual cycles.After treatment,the clinical evaluations were evaluated,the TCM symptom scores,the levels of estradiol,progesterone,FSH and LH,and SF-36 scores in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was significantly higher than that of the control group(95.45%vs 81.82%,P<0.05).Compared with before treatment,after treatment,the scores of symptoms of lower abdominal pain,fatigue,lumbosacral pain,low qi and lazy speech were significantly reduced(P<0.05),compared with the control group,after treatment,the scores of symptoms of various TCM were lower(P<0.05).After treatment,the levels of estradiol and progesterone were significantly increased,but the levels of FSH and LH were significantly decreased(P<0.05).Compared with the control group,the levels of estradiol and progesterone were higher in the treatment group after treatment,but the levels of FSH and LH were lower(P<0.05).After treatment,the SF-36 scores in two groups were significantly increased(P<0.05),and the overall health,mental health and physical pain scores of the treatment group were higher than those of the control group(P<0.05).Conclusion Compound Yimucao Capsules combined with norethisterone in treatment of menstrual irregularities has a good clinical effect,which can effectively regulate the level of hormones,improve patients'TCM symptoms and quality of life.
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