Clinical observation of Fuke Zhixueling Capsules combined with desogestrel and ethinylestradiol in treatment of dysfunctional uterine bleeding
Objective To explore the therapeutic effect of Fuke Zhixueling Capsules combined with desogestrel and ethinylestradiol in treatment of dysfunctional uterine bleeding.Methods A total of 104 patients with dysfunctional uterine bleeding admitted to Jiamusi Maternal and Child Health Hospital from June 2022 to August 2023 were selected and divided into control group(52 cases)and treatment group(52 cases)according to random number table method.Patients in the control group were po administered with Desogestrel and Ethinylestradiol Tablets,started on the 5th day of the menstrual cycle,the initial dosage was 1 tablet/time,twice daily,and changed to 1 tablet/time,once daily after 3 d of continuous treatment for 3 weeks.Patients in the treatment group were po administered with Fuke Zhixueling Capsules on the basis of the control group,4 capsules/time,3 times daily.Both groups were treated continuously for 3 weeks.The clinical effect and improvement time of TCM symptoms were observed in two groups,and the changes of endometrial thickness,hemoglobin and hormone indexes before and after treatment were compared.Results After treatment,the total effective rate of treatment group was 94.23%,which was significantly higher than that of control group(80.77%,P<0.05).After treatment,endometrial thickness decreased and hemoglobin level increased in both groups(P<0.05).Compared with control group,the endometrial thickness in treatment group was lower than that in control group after treatment,but the hemoglobin level was higher(P<0.05).Compared with the control group,the improvement time of waist and knee weakness,dark complexion and urination frequency in treatment group was shorter(P<0.05).Compared with before treatment,the levels of estradiol,follicle-stimulating hormone and progesterone were significantly decreased in both groups after treatment(P<0.05).Compared with control group,the levels of estradiol,follicle-stimulating hormone and progesterone in treatment group were lower after treatment(P<0.05).Conclusion Fuke Zhixueling Capsules combined with desogestrel and ethinylestradiol can obtain better treatment effect in treatment of dysfunctional uterine bleeding,and can effectively improve TCM symptoms,reduce the thickness of endometrial,increase the level of hemoglobin,which can improve the state of hormone disorder in the body with few and slight adverse reactions.
Fuke Zhixueling CapsulesDesogestrel and Ethinylestradiol Tabletsdysfunctional uterine bleedingimprovement time of TCM symptomsendometrial thicknesshemoglobinestradiolfollicle-stimulating hormoneprogesterone
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