Clinical study on Antai Yimu Pills combined with Dydrogesterone Tablets in treatment of early threatened miscarriage
Objective To investigate the clinical effectiveness of Antai Yimu Pills combined with Dydrogesterone Tablets in treatment of early threatened miscarriage.Methods Patients(99 cases)with early threatened miscarriage in Qingdao Chengyang People's Hospital from April 2021 to April 2023 were divided into control(49 cases)and treatment(50 cases)group based on different treatments.Patients in the control group were po administered with Dydrogesterone Tablets,the first dose was 40 mg,followed by three times daily for with 10 mg/time.Patients in the treatment group were po administered with Antai Yimu Pills on the basis of the control group,1 pill/time,twice daily.Patients in two groups were treated for 2 weeks.After treatment,the clinical evaluations were evaluated,the TCM syndrome scores,the levels of serum Hcy,PAPP-A,α-MSH and CA125,and the serum Th1/Th2 cytokine levels in two groups before and after treatment were compared.Results After treatment,the total clinical effective rate of the control group and the treatment group was 79.59%and 94.00%respectively,and the difference between two groups was statistically significant(P<0.05).After treatment,the TCM syndrome scores in two groups were significantly decreased(P<0.05),and the TCM syndrome scores in the treatment group were decreased more significantly(P<0.05).After treatment,the levels of serum Hcy,α-MSH and CA125 were significantly decreased,while the level of PAPP-A was significantly increased in two groups,the improvement of all indexes in the treatment group was more obvious(P<0.05).After treatment,serum Th1 cytokines THF-α and IL-2 were significantly decreased,while Th2 cytokines IL-4 and IL-10 were significantly increased in two groups,and the improvement in the treatment group was more obvious(P<0.05).Conclusion Antai Yimu Pills combined with ditroprogesterone is effective in treatment of early threatened abortion,which can not only significantly improve the symptoms of pregnant women and promote the recovery of serological indexes,but also improve the imbalance of immune function.
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