Clinical study on Compound Muni Ziqi Granules combined with emedastine in treatment of chronic urticaria
Objective To explore the clinical effect of Compound Muni Ziqi Granules combined with emedastine in treatment of chronic urticaria.Methods Patients(148 cases)with chronic urticaria in Linxi Hospital of Kailuan General Hospital from June 2021 to September 2023 were divided into control(74 cases)and treatment(74 cases)group based on different treatments.Patients in the control group were po administered with Emedastine Difumarate Sustained-release Capsules,1 grains/time,twice daily.Patients in the treatment group were po administered with Compound Muni Ziqi Granules on the basis of the control group,6 g/time,three times daily.Patients in two groups were treated for 15 d.After treatment,the clinical evaluations were evaluated,the symptom relief time,the scores of UAS and GU-Q2oL,the levels of serum IL-33,SAA,D-D and INF-γ in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 95.94%,which was significantly higher than that of the control group(86.49%,P<0.05).After treatment,the time of symptom relief in the treatment group was significantly earlier than that in the control group(P<0.05).After treatment,the scores of UAS and GU-Q2oL in two groups were significantly lower(P<0.05),and the scores in the treatment group were lower than those in the control group(P<0.05).After treatment,the levels of serum IL-33,SAA and D-D in two groups were significantly decreased,while the level of INF-γ was significantly increased(P<0.05),and which in the treatment group was significantly better than that in the control group(P<0.05).Conclusion Compound Muni Ziqi Granules combined with emedastine in treatment of chronic urticaria can effectively improve the clinical symptoms,significantly improve the ability and quality of life of urticaria,and weaken the inflammatory reaction.
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