Clinical study on Kouyanqing Granules combined with ganciclovir in treatment of herpetic stomatitis
Objective To investigate the clinical effect of Kouyanqing Granules combined with Ganciclovir Tablets in treatment of herpetic stomatitis.Methods Patients(92 cases)with herpetic stomatitis in Tianjin Yellow River Hospital from June 2021 to July 2023 were divided into control and treatment groups according to the random number method,and each group had 46 cases.Patients in the control group were po administered with Ganciclovir Tablets,2 tablets/time,three times daily.Patients in the treatment group were po administered with Kouyanqing Granules on the basis of the control group,2 bags/time,twice daily.Patients in two groups were treated for 7 d.The clinical efficacies,the disappearance time of the main symptoms,the change of the area of the oral mucosal lesion,the subjective pain degree,serum factors in two groups were compared.Results After treatment,the total effective rate of the treatment group was 93.48%,while the total effective rate of the control group was 76.09%,with a significant difference between two groups(P<0.05).After treatment,the disappearance times of fever,drooling,refusal to eat,and herpes in the treatment group was significantly shorter than that in the control group,with significant differences between the groups(P<0.05).After treatment,the area of oral mucosal lesions and VAS scores in two groups were smaller than those before treatment(P<0.05),and the area of oral mucosal lesions and VAS scores in the treatment group were smaller than those in the control group(P<0.05).After treatment,the positive rates of HSV-IgM and HSV-IgG in two groups significantly decreased(P<0.05);the positive rates of HSV-IgM and HSV-IgG in the treatment group were lower than those in the control group(P<0.05).After treatment,the serum levels of IL-6 and CRP in two groups were lower than before treatment(P<0.05),and the serum levels of IL-6 and CRP in the treatment group were lower than those in the control group(P<0.05).Conclusion Kouyanqing Granules combined with Ganciclovir Tablets can improve the curative effect in treatment of herpetic stomatitis,further reduce the clinical symptoms and pain,reduce the area of lesion,and reduce inflammation.
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