Literature analysis of adverse reactions induced by semaglutide
Objective To investigate the regularity and clinical characteristics of adverse drug reactions of semaglutide in order to provide reference for clinical medication.Methods Case reports of the adverse drug reactions induced by semaglutide were retrieved from the databases of CNKI,Wanfang,VIP,PubMed,Web of Science and Embase,etc.Results A total of 27 cases were reported in 21 papers,including 10 males(37.04%)and 17 females(62.96%).The mean age of the patients was(52.19±17.05)years old.Semaglutide was mainly used for diabetes mellitus and weight loss,and adverse drug reactions occurred mostly within 2 months(19 cases,70.37%),mainly involving gastrointestinal system,immune system,hepatobiliary system,kidney and urinary system,etc.After drug withdrawal and symptomatic treatment,25 patients improved and 2 patients had no obvious improvement.Conclusion It is necessary to strengthen the understanding and monitoring the adverse drug reactions induced by semaglutide,and timely perform diagnosis and treatment of the adverse drug reactions to ensure medication safety.
semaglutideadverse drug reactionliterature analysisdiabetes mellitusweight loss
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