Pharmacodynamic study of Tongfeng Kangning Tables in treatment of gouty arthritis
Objective To evaluate the effectiveness of Tongfeng Kangning Tables in prophylactic and therapeutic of gouty arthritis in various experimental models.Methods To observe the preventive and therapeutic effects of Tongfeng Kangning Tables on acute and chronic gouty arthritis in rats induced by microcrystalline sodium urate(MSU).The anti-inflammation effect of Tongfeng Kangning Tables was observed by using cotton ball granuloma model in rats.Blood stasis rat model was used to observe the blood-activating effect of Tongfeng Kangning Tables.The analgesic effect of gout Tongfeng Kangning Tables was observed by using acetic acid writhing model in mice.Results Compared with model group,prophylactic administration of Tongfeng Kangning Tables in 1.15 and 2.3 g/kg groups could significantly reduce the swelling of right ankle joint induced by MSU,improve gait,and reduce the contents of IL-1β and IL-6 in serum.Tongfeng Kangning Tables in 1.15 and 2.3 g/kg groups could significantly reduce the swelling of the right ankle and improve the gait induced by MSU.The contents of IL-1β,IL-6,tumor necrosis factor-α(TNF-α)and the number of phagocytic cells in the balloon lavage fluid of chronic arthritis rats were significantly reduced in the 1.15 and 2.3 g/kg Tongfeng Kangning Tables groups.Tongfeng Kangning Tables in 1.15 and 2.3 g/kg groups could significantly reduce the weight of cotton ball granulation.Tongfeng Kangning Tables in 0.58,1.15,and 2.3 g/kg groups significantly inhibited the increase of whole blood viscosity of blood stasis rats.Tongfeng Kangning Tables 1.66 and 3.33 g/kg groups significantly reduced the number of body twisting induced by acetic acid.Conclusion Tongfeng Kangning Tables has obvious anti-inflammatory,analgesic and blood-activating effects,and has obvious therapeutic effects on gouty arthritis.
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