Clinical study on Chuanzhi Tongluo Capsules combined with tirofiban in treatment of acute cerebral infarction
Objective To explore the therapeutic effect of Chuanzhi Tongluo Capsules combined with tirofiban in treatment of acute cerebral infarction within 48 h.Methods Patients(103 cases)with acute cerebral infarction in Zibo Central Hospital from June 2022 to June 2023 were divided into control(51 cases)and treatment(52 cases)group based on different treatments.Patients in the control group were administered with Tirofiban Hydrochloride Injection,the initial drip speed was 0.4 µg/(kg∙min)for 30 min,then the drug was administered continuously at a rate of 0.1 µg/(kg∙min).Patients in the treatment group were po administered with Chuanzhi Tongluo Capsules on the basis of the control group,2 grains/time,three times daily.Patients in two groups were treated for 14 d.After treatment,the clinical evaluations were evaluated,the scores of TCM syndrome,Barthel index,and NIHSS,the levels of serum SOD,GSH-Px,CAT,CX3CL1,bFGF and Sortilin in two groups before and after treatment were compared.Results After treatment,the total clinical effective rate of the control group and the treatment group was 78.43% and 94.23% respectively,and the difference between the two groups was statistically significant(P<0.05).After treatment,the TCM syndrome and NIHSS score in two groups were significantly decreased,while the Barthel index score was significantly increased(P<0.05),and the scores of the treatment group was significantly better than that of the control group(P<0.05).After treatment,the levels of oxidative stress indexes SOD,GSH-Px,CAT and bFGF in two groups were significantly increased,while the levels of CX3CL1 and Sortilin were significantly decreased(P<0.05),and the improvement of all indexes in the treatment group was particularly prominent(P<0.05).Conclusion The combination of Chuanzhi Tongluo Capsules and tirofiban has a significant therapeutic effect on the acute phase of cerebral infarction within 48 h,which can not only significantly improve the patient's neurological function and independent living ability,but also promote the recovery of serological indicators and effectively improve oxidative stress damage.
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