Clinical study on Qishen Yiqi Dropping Pills combine with tirofiban in treatment of acute myocardial infarction
Objective To explore the clinical efficacy of Qishen Yiqi Dropping Pills combine with Tirofiban Hydrochloride and Sodium Chloride Injection in treatment of acute myocardial infarction.Methods According to the random number table method,117 acute myocardial infarction patients who were admitted to Tianjin First Central Hospital from January 2020 to June 2022 were divided into control group(58 cases)and treatment group(59 cases).The control group received intravenous infusion of Tirofiban Hydrochloride and Sodium Chloride Injection.The initial 30 min administration rate was 0.4 μg/(kg∙min),followed by a maintenance dose of 0.1 μg/(kg∙min),once daily.The treatment group takes Qishen Yiqi Dropping Pills half an hour after meals on the basis of the control group,1 bag/time,3 times daily.Both groups of patients were treated for 4 weeks.The efficacy,number of angina pectoris attacks,duration,hemorheology index,inflammatory factor index,oxidative stress index,and recurrence rate were compared between two groups.Results After treatment,compared with the total effective rate of 82.76% in control group,the total effective rate of 94.92% in treatment group was higher(P<0.05).After treatment,the frequency and duration of angina attacks in both groups were significantly reduced(P<0.05).The number of angina attacks in the treatment group was less than that in the control group,and the duration was shorter than that in the control group(P<0.05).After treatment,fibrinogen,hematocrit,plasma viscosity,whole blood high shear viscosity,whole blood low shear viscosity,and erythrocyte sedimentation rate significantly decreased in both groups(P<0.05),and the hemorheological indicators in the treatment group were lower than those in the control group(P<0.05).After treatment,the serum levels of TNF-α,IL-6,and IL-1β in both groups significantly decreased,while the levels of serum IL-10 significantly increased(P<0.05).Moreover,the levels of TNF-α,IL-6,and IL-1β in treatment group were lower than those in control group,but the levels of serum IL-10 were higher than those in the control group(P<0.05.After treatment,the serum levels of GSH and SOD were significantly increased in both groups,while the serum levels of MDA were significantly decreased(P<0.05).Moreover,the serum levels of GSH and SOD in the treatment group were higher than those in the control group,while the serum MDA levels were lower than those in the control group(P<0.05).Conclusion The combination of Qishen Yiqi Dropping Pills and Tirofiban Hydrochloride Sodium Chloride Injection in treatment of acute myocardial infarction can improve clinical efficacy,improve clinical symptoms of patients,reduce recurrence rate,and may be related to improving hemorheology,reducing oxidative stress,and lowering levels of inflammatory factors.
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