Objective To investigate the therapeutic effect of Zhenxintong Oral Liquid combined with isosorbide mononitrate in treatment of angina pectoris.Methods A total of 86 patients with angina pectoris with coronary heart disease admitted to Wuhan Traditional Chinese Medicine Hospital from July 2022 to October 2023 were selected.According to drug use,all patients were divided into control group and treatment group,with 43 cases in each group.Patients in control group were po administered with Isosorbide Mononitrate Sustained-Release Tablets,40 mg/time,once daily.Patients in treatment group were po administered with Zhenxintong Oral Liquid on the basis of the control group,20 mL/time,three times daily.The two groups were treated for 12 weeks to observe the treatment.The clinical efficacy and symptom remission time of two groups were observed,and the changes of the Seattle Angina Rating Scale(SAQ)score,the European five-dimension Health Quality of Life Questionnaire(EQ-5D)score,vascular pseudomelophiliac factor(vWF),homocysteine(Hcy),nitric oxide(NO),and P-selectin levels before and after treatment were compared between two groups.Results After treatment,the total effective rate of treatment group was 95.35%,which was significantly higher than that of control group(79.07%,P<0.05).After treatment,the relief time of chest tightness,chest pain,palpitation and physical inactivity in treatment group was significantly shorter than that in control group(P<0.05).After treatment,the duration and frequency of angina pectoris in 2 groups were significantly decreased compared with before treatment(P<0.05).After treatment,the duration and frequency of angina pectoris in treatment group were lower than those in control group(P<0.05).After treatment,SAQ score and EQ-5D score were significantly increased in both groups(P<0.05).After treatment,SAQ scores and EQ-5D scores in treatment group were higher than those in control group(P<0.05).After treatment,serum Hcy,vWF and P-selectin levels in 2 groups were significantly decreased,but NO levels were significantly increased(P<0.05).After treatment,the levels of Hcy,vWF and P-selectin in treatment group were lower than those in control group,and the level of NO was higher than that in control group(P<0.05).Conclusion Zhenxintong Oral Liquid combined with isosorbide mononitrate has good clinical efficacy in treatment of angina pectoris,and can effectively improve the clinical symptoms of patients,weaken the inflammatory response of the body,and improve the life quality,which is worth learning and application.
Zhenxintong Oral LiquidIsosorbide Mononitrate Sustained-Release Tabletscoronary heart disease angina pectorisduration of anginathe number of angina attacksSAQ scoreEQ-5D scorevWFHcyNO
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