Clinical study on Xinmaitong Capsules combined with rosuvastatin in treatment of hyperlipidemia
Objective To explore the therapeutic effect of Xinmaitong Capsules combined with rosuvastatin in treatment of hyperlipidemia.Methods Patients(84 cases)with hyperlipidemia in Yulin Hospital,the First Affiliated Hospital of Xi'an Jiaotong University from March 2021 to September 2023 were randomly divided into control(42 cases)and treatment(42 cases)group.Patients in the control group were po administered with Rosuvastatin Calcium Tablets,5 mg/time,once daily.Patients in the treatment group were po administered with Xinmaitong Capsules on the basis of the control group,4 grains/time,three times daily.Patients in two groups were treated for 8 weeks.After treatment,the clinical evaluations were evaluated,the levels of total cholesterol,triglyceride,non-HDL-C,LDL-C,endothelin-1,CGRP,hs-CRP and MCP-1 in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 95.24%,which was significantly higher than that of the control group(80.95%,P<0.05).After treatment,the levels of total cholesterol,triglyceride,non-HDL-C,LDL-C,endothelin-1,hs-CRP and MCP-1 were significantly decreased,while the level of CGRP was significantly increased in two groups(P<0.05).Compared with the control group,the indexes in the treatment group were improved more significantly(P<0.05).Conclusion The combination of rosuvastatin and Xinmaitong Capsules in treatment of hyperlipidemia can effectively improve the lipid-lowering effect,achieve satisfactory therapeutic effects,and play a role in protecting vascular endothelial function,improving the patient's micro inflammatory state.
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