Clinical study on Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with nikozamide in treatment of acute exacerbation of chronic respiratory failure
Objective To investigate the clinical effect of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with Nikethamide Injection in treatment of acute exacerbation of chronic respiratory failure.Methods Selecting 70 patients with chronic respiratory failure admitted to Linquan County People's Hospital from January 2022 to December 2023,all patients were divided into a control group and a treatment group using computer randomization method,with 35 patients in each group.Patients of the control group was intravenously injected with Nikethamide Injection,1 tube/time,and if necessary,repeated administration within 1—2 h.Patients of the treatment group received intravenous infusion of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection on the basis of the control group,10 mL was added to 250 mL of physiological saline and fully diluted,10 mL/time,once daily.Patients of two groups received continuous treatment for 10 d.The clinical efficacy,the severity of the condition,health status,lung function indicators,blood gas analysis indicators,and serum indicators in two groups were compared.Results The total effective rates of the treatment group and the control group were 94.29％ and 77.14％,with statistically significant differences between the groups(P<0.05).After treatment,APACHE Ⅱ scores and CAT scores of two groups significantly decreased(P<0.05),and APACHE Ⅱ scores and CAT scores of the treatment group were lower than those of the control group(P<0.05).After treatment,FEV1/FVC and PEF％ pre of two groups were higher than before treatment,while RV/TLC was lower than before treatment(P<0.05).FEV1/FVC and PEF％ pre in the treatment group were higher than those in the control group,while RV/TLC was lower than those in the control group(P<0.05).After treatment,the oxygenation index,blood oxygen saturation,and oxygen partial pressure of two groups significantly increased(P<0.05),and the oxygenation index,blood oxygen saturation,and oxygen partial pressure of the treatment group were significantly higher than those of the control group(P<0.05).After treatment,HCAR,NLR,and PLR of two groups were significantly decreased(P<0.05),and HCAR,NLR,and PLR of the treatment group were lower than those of the control group(P<0.05).Conclusion The combination of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection and Nikethamide Injection can improve the therapeutic effect of chronic respiratory failure,further reduce the severity of the condition,improve health status,enhance lung function,and reduce inflammatory reactions.
Salviae Miltiorrhizae and Ligustrazine Hydrochloride InjectionNikethamide Injectionacute exacerbation of chronic respiratory failureAPACHE Ⅱ scoreFEV1/FVCRV/TLCblood oxygen saturationHCAR
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