Clinical study of Xuebijing Injection combined with ceftazidime in treatment of multidrug-resistant Klebsiella pneumoniae pneumonia
Objective To explore the clinical efficacy of Xuebijing Injection combined with ceftazidime in treatment of multidrug-resistant Klebsiella pneumoniae pneumonia.Methods A total of 106 patients with multidrug-resistant klebsiella pneumoniae pneumonia admitted to the Second People's Hospital of Liaocheng from August 2020 to February 2023 were selected and divided into control group and treatment group according to random number table method,with 53 cases in each group.Patients in control group were iv administered with Ceftazidime for injection,2 g was added to 0.9% normal saline 100 mL,once 12 h.Patients in treatment group were po administered with Xuebijing Injection on the basis of the control group,50 mL was added to 0.9% normal saline 100 mL,twice daily,each infusion time from 30 to 40 min.The treatment course of both groups was 14 d.Clinical treatment and disappearance time of clinical manifestations of the two groups were observed,and the changes of oxygenation index(OI),respiratory rate(RR),PCRAES score,whole blood C-reactive protein(CRP),serum procalcitonin(PCT),interleukin-6 and amyloid A(SAA)levels before and after treatment were compared between two groups.Results After treatment,the total effective rate of treatment group was 94.34%,which was significantly higher than that of control group(81.13%,P<0.05).After treatment,the disappearance time of fever,cough,sputum,lung rales and leukocyte abnormalities in 2 groups was significantly shorter than that in control group(P<0.05).After treatment,OI was significantly increased in both groups,but RR and PCRAES scores were significantly decreased(P<0.05).After treatment,the improvement of OI,RR and PCRAES scores in treatment group was better than that in control group(P<0.05).After treatment,whole blood CRP and serum PCT,IL-6 and SAA levels in both groups were significantly decreased(P<0.05).After treatment,whole blood CRP,serum PCT,IL-6 and SAA levels in treatment group were significantly lower than those in control group(P<0.05).Conclusion Xuebijing Injection combined with ceftazidime has exact effect in treatment of multidrug-resistant Klebsiella pneumoniae pneumonia,and can effectively control the clinical manifestations of patients,relieve airway blockage,enhance respiratory function,which can relieve lung infection and body inflammation.
Xuebijing InjectionCeftazidime for injectionKlebsiella pneumoniae pneumoniamultidrug resistant bacteriatime for clinical manifestations to disappearOIRRPCRAES scoreCRPPCTIL-6SAA
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