Clinical study of acetylcysteine combined with aminophylline in treatment of acute attack of chronic asthmatic bronchitis
Objective To analyze the clinical efficacy of inhaled acetylcysteine solution combined with aminophylline in the treatment of acute attack of chronic asthmatic bronchitis.Method:156 patients with acute exacerbations of chronic asthmatic bronchitis admitted to Xi'an Eighth Hospital from December 2021 to June 2023 were randomly divided into two groups using a random number table method,78 cases in each group.Patients in the control group were iv administered with Aminophylline Injection,0.25 g was dissolved in 5% glucose solution 250 mL,3 times daily.Patients in treatment group were atomized inhalation Acetylcysteine Solution for inhalation on the basis of the control group,3 mL/time,twice daily.Both groups were treated for 7 d.The clinical effects of two groups and the main performance time were observed,and the lung function index,breath(FeNO),nitric oxide in induced sputum eosinophils(EOS),serum c-reactive protein(CRP),endothelin 1(ET 1),interleukin 8(IL-8)in two groups before and after treatment were compared.Results After treatment,the total effective rate of the treatment group was 96.15%,which was significantly higher than that of the control group(87.18%,P<0.05).After treatment,the remission time of wheezing,phlegm,cough and wheezing in the treatment group was significantly shorter than that in the treatment group(P<0.05).After treatment,forced vital capacity(FVC),forced expiratory flow rate(MMEF),forced expiratory volume in the first second(FEV1),ratio of deep inspiratory volume to total lung volume(IC/TLC)in 2 groups were significantly increased compared with before treatment(P<0.05).After treatment,the improvement of lung function indexes in the treatment group was better than that in the control group(P<0.05).After treatment,FeNO,EOS proportion in induced sputum and serum CRP,ET-1 and IL-8 levels were significantly decreased in both groups(P<0.05).After treatment,FeNO,EOS ratio in induced sputum and serum CRP,ET-1 and IL-8 levels in the treatment group were better than those in the control group(P<0.05).Conclusion:Inhaled acetylcysteine solution combined with aminophylline has good effect and safety in the treatment of acute attack of chronic asthmatic bronchitis,and can quickly alleviate the main clinical manifestations of patients,inhibit airway inflammation and body inflammatory injury,reduce respiratory resistance,and promote the improvement of lung function,which is worthy of promotion and application.
Acetylcysteine Solution for inhalationAminophylline Injectionacute attack of chronic asthmatic bronchitismajor clinical manifestations relief timepulmonary function indexFeNOthe proportion of EOS in induced sputumCRPET-1IL-8
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