Clinical study on Chushi Zhiyang Ointment combined with Compound Triamcinolone Acetonide Cream in treatment of perianal eczema
Objective To explore the clinical efficacy of Chushi Zhiyang Ointment combined with Compound Triamcinolone Acetonide Cream in treatment of perianal eczema.Methods Patients(82 cases)with perianal eczema in Shanghai Xuhui District Dahua Hospital from February 2021 to January 2024 were divided into control and treatment groups according to the computer random arrangement method,and each group had 41 cases.Patients in the control group were applied topically with Compound Triamcinolone Acetonide Cream,once in the morning and once in the evening,1 fingertip unit(FTU)/time.Patients in the treatment group were applied topically with Chushi Zhiyang Ointment on the basis of the control group,1 FTU/time,three times daily.Patients in two groups were treated for 4 weeks.After treatment,the clinical efficacies,the eczema symptoms,severity,and serum indicators in two groups were compared.Results After treatment,the total effective rate was 95.12% in the treatment group,and the total effective rate was 78.05% in the control group,and the difference between groups was statistically significant(P<0.05).After treatment,the frequency and duration of perianal eczema,and the score of itch degree in two groups were significantly decreased(P<0.05),and the frequency and duration of perianal eczema,and the score of itch degree in the treatment group were significantly lower than those in the control group(P<0.05).After treatment,the EASI score of two groups was significantly decreased(P<0.05),and the EASI score of the treatment group was significantly lower than that of the control group(P<0.05).After treatment,the serum levels of IL-17,LTB4,and IL-4 in two groups were significantly decreased(P<0.05),and the serum levels of IL-17,LTB4,and IL-4 in the treatment group were lower than those in the control group(P<0.05).Conclusion Chushi Zhiyang Ointment combined with Compound Triamcinolone Acetonide Cream can improve the therapeutic effect of perianal eczema,improve itching symptoms,control the condition,and reduce inflammation reactions.
Chushi Zhiyang OintmentCompound Triamcinolone Acetonide Creamperianal eczemafrequencyduration of perianal eczemascore of itching degreeEASI scoreIL-17LTB4IL-4
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