Clinical study on canagliflozin combined with nateglinide in treatment of type 2 diabetes
Objective To explore the clinical effect of canagliflozin combined with nateglinide in treatment of type 2 diabetes.Methods Patients(96 cases)with type 2 diabetes in the Second People's Hospital of Liaocheng from April 2022 to June 2023 were divided into control(48 cases)and treatment(48 cases)group based on different treatments.Patients in the control group were po administered with Nateglinide Tablets,120 mg/time,three times daily.Patients in the treatment group were po administered with Canagliflozin Tablets on the basis of the control group,100 mg/time,once daily.Patients in two groups were treated for 12 weeks.After treatment,the clinical evaluations were evaluated,the blood glucose metabolism indicators FBG,PBG,HbA1c and FINS,DMQLS scores and HOMA-IR indexes,and the levels of MCP-1,IL-6,TNF-α and GLP-1 in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 95.83%,which was significantly higher than that of the control group(83.33%,P<0.05).After treatment,the levels of FBG,PBG,HbA1c,FINS,MCP-1,IL-6,TNF-α and HOMA-IR index were significantly decreased,while GLP-1 level and DMQLS score were significantly increased in two groups(P<0.05),and the indexes in the treatment group were significantly better than those in the control group(P<0.05).Conclusion The combination of categlinide and nateglinide can greatly correct the elevated blood sugar,improve the insulin secretion,improve the quality of life and decrease the content of inflammatory factors.
NETL
NSTL
万方数据
