Clinical study on Quanduzhong Capsules combined with alendronate sodium in treatment of elderly osteoporosis
Objective To explore the therapeutic effect of Quanduzhong Capsules combined with alendronate sodium in treatment of elderly osteoporosis.Methods Patients(98 cases)with elderly osteoporosis in XD Group Hospital from March 2020 to August 2023 were divided into control(49 cases)and treatment(49 cases)group according to the random number table method.Patients in the control group were po administered with Alendronate Sodium Tablets 30 min before breakfast,10 mg/time,once daily.Patients in the treatment group were po administered with Quanduzhong Capsules on the basis of the control group,2 grains/time,twice daily.Patients in two groups were treated for 3 months.After treatment,the clinical evaluations were evaluated,the improvement time of TCM symptoms,the levels of bone metabolism indicators CTX,TNF-α and NTX,and bone density levels in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 95.92%,which was significantly higher than that of the control group(81.63%,P<0.05).Compared with the control group,the improvement time of loose stool,cold pain of waist and knees,fear of cold and warmth,sore waist and knees in the treatment group was significantly shorter than that in the control group(P<0.05).The levels of serum CTX,TNF-α and NTX in two groups were significantly lower than those before treatment(P<0.05),and the levels of serum CTX,TNF-α and NTX in the treatment group were lower than those before treatment(P<0.05).Compared with those before treatment,the bone mineral density of femoral neck and lumbar vertebrae in two groups was significantly increased(P<0.05),and the bone mineral density in the treatment group was higher than that in the control group(P<0.05).Conclusion Quanduzhong Capsules combined with alendronate sodium combined with alendronate can quickly improve the TCM symptoms,increase the level of bone mineral density and effectively regulate bone metabolism.
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