Clinical study on Chanhou Zhuyu Capsules combined with carboprost tromethamine in treatment of postpartum hemorrhage
Objective To investigate the clinical effect of Chanhou Zhuyu Capsules combined with Carboprost Tromethamine Injection in treatment of postpartum hemorrhage.Methods Patients(86 cases)with postpartum hemorrhage in Tianjin Peking University Medical Offshore Oil Hospital from January 2022 to December 2023 were randomly divided into control and treatment groups according to different treatment plans,and each group had 43 cases.Patients in the control group were im administered with Carboprost Tromethamine Injection,1 piece/time,once daily.Patients in the treatment group were po administered with Chanhou Zhuyu Capsules on the basis of the control group,3 grains/time,three times daily.Patients in two groups were treated for 2 d.The clinical efficacies,postpartum bleeding volume,uterine involution,and serum indicators in two groups were compared.Results The cure rate in the treatment group(93.02％ )was significantly higher than 76.74％ in the control group,and the difference was significant between groups(P<0.05).The amounts of blood loss 2 h and 2—24 h after delivery in the treatment group was lower than those in the control group(P<0.05).After treatment,the area of uterine residue and three diameters of uterus in two groups were lower than those before treatment(P<0.05),and the area of uterine residue and the uterine diameter of the treatment group were lower than those of the control group(P<0.05).After treatment,the levels of AT-Ⅲ in two groups were significantly increased,while the levels of FIB and D-D in two groups were significantly decreased(P<0.05).The levels of AT-Ⅲ in the treatment group were higher than those in the control group,while the levels of FIB and D-D in the treatment group were lower than those in the control group(P<0.05).Conclusion Chanhou Zhuyu Capsules combined with Carboprost Tromethamine Injection has clinical effect in treatment of postpartum hemorrhage,can reduce bleeding volume,promote uterine involution,regulate coagulation and fibrinolysis functions.
Chanhou Zhuyu CapsulesCarboprost Tromethamine Injectionpostpartum hemorrhageblood lossresidual area of uterusthree diameters of uterusAT-ⅢFIBD-D
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