Clinical study on Xiaoer Qingqiao Granules combined with amoxicillin and clavulanate potassium in treatment of acute suppurative tonsillitis in children
Objective To explore the clinical effect of Xiaoer Qingqiao Granules combined with amoxicillin and clavulanate potassium in treatment of acute suppurative tonsillitis in children.Methods Children(112 cases)with acute suppurative tonsillitis from August 2021 to August 2023 were divided into control(56 cases)and treatment(56 cases)group based on different treatments.Children in the control group were po administered with Amoxicillin and Clavulanate Potassium Tablets,5 years≤age<7 years,half tablet/time,7 years≤age<12 years,1 tablet/time,twice daily.Children in the treatment group were po administered with Xiaoer Qingqiao Granules on the basis of the control group,5 years≤age<7 years,7.5 g/time,twice daily,7 years≤age<12 years,7.5 g/time,3 times daily.Children in two groups were treated for 7 d.After treatment,the clinical evaluations were evaluated,the symptom relief time,the PSQI scores,the levels of serum IL-1β,WBC,TNF-α and PCT in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 96.28%,which was significantly higher than that of the control group(83.92%,P<0.05).After treatment,the improvement time of symptoms such as sore throat,fever and enlarged tonsil in the treatment group was significantly earlier than that in the control group(P<0.05).After treatment,the PSQI score in two groups was significantly decreased(P<0.05),and the score in the treatment group was significantly lower than that of the control group(P<0.05).After treatment,the serum levels of IL-1β,WBC,TNF-α and PCT in two groups were significantly decreased(P<0.05),which in the treatment group were significantly lower than that in the control group(P<0.05).Conclusion The synergistic treatment of Amoxicillin and Clavulanate Potassium Tablets and Xiaoer Qingqiao Granules can effectively improve the symptoms of tonsillitis,significantly improve the sleep quality and weaken the local inflammatory reaction.
Xiaoer Qingqiao GranulesAmoxicillin and Clavulanate Potassium Tabletsacute suppurative tonsillitis in childrenPSQIPCTWBC
NETL
NSTL
万方数据
