Clinical observation of Zhichuanling Oral Liquid in treatment of cough variant asthma in children(wind-heat attacking lung syndrome)
Objective To investigate the therapeutic effect of Zhichuanling Oral Liquid in treatment of cough variant asthma in children(wind-heat attacking lung syndrome).Methods A total of 60 children with cough-variant asthma treated in the pediatric outpatient department of the Affiliated Hospital of Nanjing University of Chinese Medicine from November 2021 to December 2022 were selected and divided into control group(33 cases)and treatment group(27 cases)according to random number table method.Patients in the control group were po administered with Montelukast Sodium Oral Granules,children≤2 years old and children<5 years old were given Montelukast Sodium Granules with warm water,4 mg/time,once a night.Children≤5 years old Children<14 years old swallowed Montelukast Sodium Chewable Tablets after chewing,5 mg/time,once a night.Children in the treatment group were po administered with Zhichuanling Oral Liquid,2 years≤children<3 years,3 mL/time,3 years old≤children<9 years,6 mL/time,≥10 years old,10 mL/time,3 times daily.Both groups were treated for 2 weeks.The clinical efficacy of the two groups was observed,and the main symptom score,secondary symptom score and total TCM syndrome score of the two groups were compared.Results After treatment,the control rate of the treatment group was 63.0%,significantly higher than that of the control group(21.2% )(P<0.05).The total effective rate was 96.3% in the treatment group and 90.9% in the control group.There was no significant difference between the two groups.After treatment,the score of cough severity,cough frequency and total score of main disease in two groups were significantly decreased compared with that before treatment(P<0.05).After treatment,the main symptom score of the treatment group was significantly lower than that of the control group(P<0.05).After treatment,thirst score,throat pain score,runny nose score,nasal congestion score and total score were significantly decreased in two groups(P<0.05).After treatment,the thirst score of treatment group was significantly lower than that of control group(P<0.05).The total score of TCM syndromes in two groups after 1 and 2 weeks of treatment was significantly lower than that before treatment(P<0.05).The total score of TCM syndrome in the treatment group was significantly lower than that in the control group(P<0.05).Conclusion Zhichuanling Oral Liquid has a remarkable effect in treatment of cough variant asthma in children(wind-heat attacking lung syndrome),and can significantly improve the cough symptoms of children,and can be applied to the wind-heat attack lung syndrome of children with cough variant asthma.The medicine has simple taste,convenient administration and good safety.
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