Clinical study on Runfei Ointment combined with ambroxol and clenbuterol in treatment of chronic bronchitis during acute stage in children
Objective To investigate the clinical effect of Runfei Ointment combined with Ambroxol Hydrochloride and Clenbuterol Hydrochloride Oral Solution in treatment of chronic bronchitis during acute stage in children.Methods Children(120 cases)with chronic bronchitis during acute stage admitted to Shijiazhuang Maternal and Child Health Hospital from February 2021 to January 2024 were selected.All children were divided into control and treatment group using a random number table method,with 60 cases in each group.In the control group,children took Ambroxol Hydrochloride and Clenbuterol Hydrochloride Oral Solution,7.5 mL/time at the age of 2 to 3,10 mL/time at the age of 4 to 5,15 mL/time at the age of 6 to 12,and 20 mL/time at the age of 12 and above,twice daily.On the basis of the control group,the children in the treatment group were po administered with Runfei Ointment with boiled water for 15 g/times,twice daily.Children in both groups were treated for 7 days.The clinical efficacy,the symptom relief time,ventilation function index,and serum inflammation index were compared between two groups.Results After treatment,the total effective rate of the treatment group(95.00% )was significantly higher than that of the control group(83.33% ),and the difference was statistically significant(P<0.05).After treatment,the remission time of fever,daytime cough,nighttime cough,wheezing,and pulmonary rales in the treatment group was significantly shorter than those in the control group,and the difference was statistically significant(P<0.05).After treatment,BF and TI/TE of two groups were lower than those before treatment,but VT of two groups was higher than those before treatment(P<0.05).BF and TI/TE in the treatment group were lower than those in the control group,but VT in the treatment group was higher than those in the control group(P<0.05).After treatment,the serum levels of hs-CRP and TNF-α were lower than before treatment,but the serum levels of MBL were higher than before treatment(P<0.05).The serum levels of hs-CRP and TNF-α in the treatment group were lower than those in the control group,but the serum levels of MBL in the treatment group were higher than those in the control group(P<0.05).Conclusion Runfei Semifluid Extract combined with Ambroxol Hydrochloride and Clenbuterol Hydrochloride Oral Solution can improve the clinical effect of pediatric bronchitis,improve the efficiency of symptom improvement,reduce inflammation and improve lung ventilation function.
Runfei OintmentAmbroxol Hydrochloride and Clenbuterol Hydrochloride Oral Solutionchronic bronchitis during acute stage in childrensymptom relief timeBFTI/TEVThs-CRPTNF-αMBL
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