Clinical study on Xiao'er Xiaoji Zhike Oral Liquid combined with budesonide in treatment of chronic cough infected with Mycoplasma pneumoniae in children
Objective To observe the clinical efficacy of Xiao'er Xiaoji Zhike Oral Liquid combined with Budesonide Suspension for inhalation in treatment of chronic cough after infected with Mycoplasma pneumoniae in children.Methods 82 Children with chronic cough after Mycoplasma pneumoniae infection who were treated in Huangshan Shoukang Hospital from January 2019 to August 2023 were selected.All children were divided into control group(41 cases)and treatment group(41 cases)according to the random number table.Children in the control group were atomized with Budesonide Suspension for inhalation,2 mL/time,twice daily.Children in the treatment group po administered with Xiao'er Xiaoji Zhike Oral Liquid on the basis of the control group,with a dosage of 5 mL/time under 1 year old,10 mL/time for those aged 1—3 years old,and 15 mL/time for those aged 3—5 years old,20 mL/time for those aged above 5 years old,three times daily.One course had 5 d,and all received 3 courses of treatment.Treatment efficacy,symptom disappearance times,and inflammatory cytokine levels between two groups were compared.Results After treatment,the total effective rate of the control group was 75.61%,while that of the treatment group was 92.68%,with a significant difference between the groups(P<0.05).Compared to the control group,the disappearance times of cough and lung rales in the treatment group was shorter(P<0.05).After treatment,the serum levels of CRP,TNF-α,and IL-6 in two groups were significantly decreased(P<0.05),and the inflammatory cytokine levels in the treatment group were lower than those in the control group(P<0.05).Conclusion Xiao'er Xiaoji Zhike Oral Liquid combined with Budesonide Suspension for inhalation has better effect on chronic cough after Mycoplasma pneumoniae infection in children,can quickly relieve cough symptoms and reduce the level of inflammatory factors.
Xiao'er Xiaoji Zhike Oral LiquidBudesonide Suspension for inhalationchronic cough infected with Mycoplasma pneumoniae in childrendisappearance time of coughdisappearance time of lung ralesCRPTNF-ɑIL-6
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