Clinical study on Xinhuang Tablets combined with minocycline in treatment of wisdom tooth pericoronitis
Objective To explore the clinical efficacy of Xinhuang Tablets combined with Minocycline Hydrochloride Ointment in treatment of wisdom tooth periodontitis.Methods Patients(88 cases)with wisdom tooth pericoronitis treated in Tianjin Occupational Disease Prevention and Therapeutic Hospital from March 2021 to February 2024 were selected and divided into control group and treatment group according to random number table method,with 44 cases in each group.Patients in the control group was filled with Minocycline Hydrochloride Ointment in the periodontal pocket of the affected area,once weekly.In the treatment group,Xinhuang Tablets was taken orally,three times daily,3 tablets/times on the basis of the control group.Patients of two groups were treated for 4 weeks.The clinical efficacy,symptom disappearance time,subjective toothache degree,gingival index,and serum inflammatory indicators between two groups were compare.Results The cure rate was 95.45% in the treatment group,81.82% in the control group,and the difference between the two groups was significant(P<0.05).After treatment,the disappearance times of tooth swelling,tooth pain,mouth opening restriction and fever in the treatment group was shorter than those in the control group(P<0.05).After treatment,VAS scores,gingival index,and serum levels of hs-CRP and PGE2 of two groups were lower than those before treatment,but the serum levels of IL-2 were higher than those before treatment(P<0.05).VAS score,gingival index,and hs-CRP and PGE2 serum levels in the treatment group were lower than those in the control group,but serum levels of IL-2 in treatment group were higher than those in control group(P<0.05).Conclusion Xinhuang Tablets combined with Minocycline Hydrochloride Ointment can improve the effect of wisdom tooth pericoronitis,improve clinical symptoms,reduce pain,improve gingival state,and reduce inflammation.
NETL
NSTL
万方数据
