Clinical study of Zhongtong'an Capsules combined with tacrolimus in treatment of erosive oral lichen planus
Objective To investigate the therapeutic effect of Zhongtong'an Capsules combined with tacrolimus in treatment of erosive oral lichen planus.Methods A total of 86 erosive oral lichen planus patients admitted to Tianjin Third Central Hospital Branch from May 2019 to July 2022 were selected,and all patients were divided into control group and treatment group according to drug use,with 43 cases in each group.Patients in control group applied Tacrolimus Ointment to the affected area,once daily.Patients in treatment group were po administered with Zhongtong'an Capsules on the basis of control group,3 grains/time,three times daily.Two groups were treated for 28 d to observe the therapeutic effect.The clinical efficacy and duration of clinical symptom remission in two groups were observed,and the changes of pain visual analogue scale(VAS),lesion erosion area,transforming growth factor β1(TGF-β1),interleukin17(IL-17),malondialdehyde(MDA),and tumor necrosis factor-α(TNF-α)before and after treatment were compared between two groups.Results After treatment,the total effective rate of the treatment group was 95.35%,which was significantly higher than that of control group(79.06%,P<0.05).After treatment,the relief time of local burning pain,dry mouth,mucosal astringency and mucosal congestion in treatment group was significantly shorter than that in control group(P<0.05).After treatment,VAS score and lesion erosion area in 2 groups were significantly decreased compared with before treatment(P<0.05).After treatment,VAS score and lesion erosion area in treatment group were lower than those in control group(P<0.05).After treatment,the serum levels of TGF-β1,IL-17,TNF-α and MDA in 2 groups were significantly decreased(P<0.05).After treatment,serological indexes in treatment group were significantly lower than those in control group(P<0.05).Conclusion Zhongtong'an Capsules combined with tacrolimus has a good clinical effect in treatment of erosive oral lichen planus,and can improve the clinical symptoms of patients,reduce the area of oral ulcer and the pain degree,and weaken the local inflammatory response,which is worthy of reference and application.
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