Oral opioid drugs are mainly used for treatment of moderate to severe cancer pain.With the increasing number of users,the abuse of oral opioid drugs is becoming increasingly apparent.The abuse of oral opioid drugs has become a key concern of the national drug regulatory authorities.This article analyzes the abuse and supervision of typical oral opioid drugs,such as hydroxycodone and its compound preparations,tramadol and its compound preparations,and Compound Diphenoxylate Tablets,and provides suggestions from different perspectives,hoping to provide reference for the regulation and rational use of oral opioid drugs in China.