Research progress on traditional Chinese medicine in treatment of psoriasis by regulating NF-κB signaling pathway
Psoriasis is a chronic autoimmune skin disease,characterized by immune dysfunction and abnormal proliferation of keratinocytes at its core.NF-κB is a key regulatory signaling pathway in psoriasis,and inhibiting the NF-κB signaling pathway or downstream transcription factors such as TNF-α or IL-17/IL-23 has become a new direction for future psoriasis treatment.Traditional Chinese medicine targeting the NF-κB signaling pathway has the advantages of definite therapeutic effect,diverse methods,and minimal adverse reactions in treatment of psoriasis.This article summarizes the research progress on traditional Chinese medicine in treatment of psoriasis by regulating MAPK/NF-κB,NF-κB/STAT3,and TLR4/NF-κB signaling pathways,with the aim of providing updated strategies for the treatment of psoriasis with traditional Chinese medicine.
traditional Chinese medicinepsoriasisNF-κBMAPK/NF-κB signaling pathwayNF-κB/STAT3 signaling pathwayTLR4/NF-κB signaling pathway
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