Progress on clinical research and mechanism of sodium-glucose cotransporter 2 inhibitors in treatment of ventricular arrhythmias
Ventricular arrhythmia is one of the important causes of sudden cardiac death.Sodium-glucose cotransporter 2(SGLT2)inhibitors can reduce the occurrence of ventricular arrhythmias.The SGLT2 inhibitors available for sale on the market include dapagliflozin,enagliflozin,canagliflozin,and etogliflozin.SGLT2 inhibitors are clinically used to treat ventricular arrhythmias,and their mechanisms of action include affecting ion channels,mitochondria and oxidative stress,myocardial fibrosis,hypoglycemia and QT interval,and energy metabolism.This article summarizes the clinical research and mechanism of action of SGLT2 inhibitors in treatment of ventricular arrhythmias,providing new ideas for exploring the treatment of ventricular arrhythmias.
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