Liver cancer is one of the most common causes of cancer death,and most types of liver cancer have high resistance to chemotherapy.Sinomenine is a morphine alkaloid extracted from the roots and stems of Cocculus trilopus.(Thunb.)DC.and it has various pharmacological effects.Sinomenine can promote tumor cell apoptosis,inhibit tumor cell proliferation,prevent tumor cell invasion and metastasis,regulate immune function,and has synergistic effects with anti-cancer drugs to prevent and treat liver cancer.This article summarizes the pharmacological research progress of sinomenine in prevention and treatment of liver cancer,hoping to provide reference for the clinical treatment of liver cancer with sinomenine.
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