Objective To analyze the clinical efficacy of troxerutin combined with tirofiban in treatment of acute progressive cerebral infarction.Methods A total of 126 patients with acute progressive cerebral infarction admitted to Bayannur Hospital from January 2020 to August 2023 were selected and divided into control group and treatment group according to random number table method,with 63 cases in each group.Patients in control group were iv administered with Tirofiban Hydrochloride and Sodium Chloride Injection,the infusion was started at 0.4 μg/(kg∙min)for 30 min,then maintained at 0.1 μg/(kg∙min)for 72 h,after which routine therapy was continued.Patients in treatment group were iv administered with Troxerutin Injection on the basis of the control group,0.3 g was dissolved in 5%glucose injection 250 mL,once daily.Patients in two groups were treated for 14 d.After treatment,the clinical efficacy was evaluated,changes of scores on relevant scales[functional comprehensive assessment(FCA),modified barthel index(MBI)],platelet parameters[mean platelet volume(MPV),platelet aggregation rate(PAgT)],and coagulation indicators[fibrinogen degradation products(FDP),D-dimer(D-D)]in two groups before and after treatment were compared.Results After treatment,the total effective rate of the treatment group was 93.65%,which was significantly higher than that of the control group(80.95%,P<0.05).After treatment,NIHSS scores were significantly decreased,but FCA and MBI scores were significantly increased in both groups(P<0.05).After treatment,NIHSS,FCA and MBI scores in the treatment group were better than those in the control group(P<0.05).After treatment,PLT in two groups was significantly higher than before treatment,while MPV and PAgT were significantly decreased(P<0.05).After treatment,the improvement of platelet parameters in the treatment group was better than that in the control group(P<0.05).After treatment,PT was significantly prolonged,while FDP and D-D were significantly decreased in both groups(P<0.05).After treatment,the improvement of coagulation index in treatment group was better than that in control group(P<0.05).Conclusion The combination of troxerutin and tirofiban is safer for the treatment of acute progressive cerebral infarction,which can effectively improve the treatment effect,reduce neurological damage,accelerate the recovery of patients'functional status,and have advantages in further regulating the body's coagulation function and inhibiting thrombosis formation.
Troxerutin InjectionTirofiban Hydrochloride and Sodium Chloride Injectionacute progressive cerebral infarctionFCA scoreMBIplatelet functioncoagulation function
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