Objective To investigate the effect of Compound Yinhua Jiedu Granules combined with Peramivir and Sodium Chloride Injection in treatment of influenza in children.Methods 130 Children with influenza admitted to Hebei Meihe Maternity and Gynecology Hospital from January 2022 to December 2023 were selected,and all children were divided into control group and treatment group according to random number table method,with 65 cases in each group.Children in the control group were iv Peramivir and Sodium Chloride Injection,once daily,10 mg/kg each time,no more than 600 mg each time,more than 30 min of single intravenous infusion,continuous administration according to the condition,no more than 5 d.On the basis of the control group,children in the treatment group were po Compound Yinhua Jiedu Granules with boiled water,1 bag/time,3 times/day,and continued treatment for 5 d.The clinical efficacy,main symptoms complete disappearance time,virus negative transformation,the state of the disease,and the inflammatory indicators were compared between two groups.Results After treatment,the total effective rate was93.85%in the treatment group,and 81.54%in the control group,with significant difference between groups(P<0.05).After treatment,the complete disappearance times of fever,cough,and nasal congestion in the treatment group was shorter than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the virus negative conversion rate in the treatment group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the symptom score,functional score,and parental influence score of the two groups were significantly decreased(P<0.05),and all CARIFS scores in the treatment group were lower than those in the control group(P<0.05).After treatment,SAA/CRP,IL-10,and NLR of the two groups were significantly decreased(P<0.05),and SAA/CRP,IL-10,and NLR in the treatment group were lower than those in the control group(P<0.05).Conclusion Compound Yinhua Jiedu Granule combined with Peramivir and Sodium Chloride Injection can improve the curative effect of influenza in children,improve clinical symptoms,promote virus negative transformation and disease development,and reduce inflammation.
Compound Yinhua Jiedu GranulesPeramivir and Sodium Chloride Injectioninfluenza in childrennasal congestion complete disappearance timevirus negative conversion rateCARIFS scoreSAA/CRPIL-10NLR
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