Objective To explore the clinical effect of Pudilan Xiaoyan Tablets combined with budesonide in treatment of acute laryngitis in children.Methods Children(100 cases)with acute laryngitis in 903 Hospital from January 2021 to December 2023 were divided into control group(50 cases)and treatment group(50 cases)according to random number table method,.Children in the control group were treated with Budesonide Suspension for inhalation,1 g/time,twice daily.Patients in the control group were po administered with Pudilan Xiaoyan Tablets,2-3 tablets/time,four times daily.Children in two groups were treated for 5 d.After treatment,the clinical effects were evaluated,the symptom improvement time,scores of signs under laryngoscope and hs-CRP,IL-10 and IL-6 in two groups were compared before and after treatment.Results After treatment,the total effective rates in the control and treatment groups were 84.00%vs 96.00%,respectively,and the difference between the two groups was statistically significant(P<0.05).After treatment,the symptom improvement time in the treatment group was shorter than that in the control group(P<0.05).After treatment,the scores of epiglottic congestion,mucus adhesion,edema,vocal cord congestion and other laryngoscopic signs in two groups were significantly decreased(P<0.05),and the scores in the treatment group were significantly lower than those in the control group(P<0.05).After treatment,the levels of hs-CRP,IL-10 and IL-6 in two groups were significantly decreased(P<0.05),and the levels in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion Pudilan Xiaoyan Tablets combined with budesonide in treatment of acute laryngitis in children has high efficacy and safety in the treatment of acute laryngitis,which can alleviate the inflammatory reaction of patients and improve laryngeal symptoms.
Pudilan Xiaoyan TabletsBudesonide Suspension for inhalationacute laryngitishs-CRPIL-10IL-6
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