Objective To investigate the therapeutic effect of Shenqi Jiangtang Capsules combined with Insulin Detemir Injection in treatment of gestational diabetes mellitus.Methods A total of 83 patients with gestational diabetes mellitus treated in Tianjin Peking University Medical Offshore Oil Hospital from February 2022 to January 2024 were selected and divided into control group(41 cases)and treatment group(42 cases)according to random number table method.Patients in the control group were sc Insulin Detemir Injection at night once daily,with an initial dose of 10 UI per injection,adjusted according to individual needs.Patients in the treatment group po administered with Shenqi Jiangtang Capsules on the basis of the control group,3 grains/time,3 times daily.Patients in two groups received continuous treatment for three months.The total effective rate,time to reach blood glucose target,and serum inflammatory factors were compared.Results After treatment,the total effective rate was 95.24%in the treatment group and 80.49%in the control group,and the difference was significant(P<0.05).After treatment,the standard times of FBG,2 h PG,and HbA1c in the treatment group was shorter than that in the control group,and the difference was statistically significant(P<0.05).After treatment,FINS and HOMA-β in the treatment group were significantly increased,but HOMA-IR in the treatment group was significantly decreased(P<0.05),and FINS and HOMA-β in the treatment group were significantly higher than those in the control group,but HOMA-IR in the treatment group was significantly lower than those in the control group(P<0.05).After treatment,the serum levels of LRG1,NLRP3,and GAS6 in the treatment group were significantly decreased(P<0.05),and the serum levels of LRG1,NLRP3,and GAS6 in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion Shenqi Jiangtang Capsules combined with Insulin Detemir Injection can improve the clinical effect of gestational diabetes mellitus,improve blood sugar and insulin function,and reduce inflammation.
Shenqi Jiangtang CapsulesInsulin Detemir Injectiongestational diabetes mellitusstandard time of FBGFINSHOMA-βHOMA-IRLRG1NLRP3GAS6
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