Objective To investigate the clinical effect of Pingxiao Capsules combined with Carrilizumab for injection in treatment of non-small cell lung cancer.Methods A total of 100 patients with non-small cell lung cancer admitted to the 986th Air Force Hospital from March 2021 to February 2024 were selected and divided into control group and treatment group according to random number table method,with 50 cases in each group.Patients in the control group were iv Carrilizumab for injection,200 mg/time,once every 3 weeks.Patients in the treatment group were po Pingxiao Capsules on the basis of the control group,4 capsules/time,3 times daily.Three weeks was one course,and patients in both groups were treated continuously for four courses.The clinical efficacy,health status,quality of life,lymphocyte,and serum indexes were compared between two groups.Results The disease control rate of treatment group and control group was 92.00%and 76.00%,respectively,and the difference was statistically significant between groups(P<0.05).After treatment,KPS scores in both groups were higher than theses before treatment(P<0.05),and KPS scores in the treatment group were higher than those in the control group(P<0.05).After treatment,the functional scores,total health scores,and symptom scores of both groups were lower than theses before treatment(P<0.05).The scores of QLQ-C30 in the treatment group were lower than those in the control group(P<0.05).After treatment,CD4+and CD4+/CD8+in both groups were higher than these before treatment(P<0.05).CD4+and CD4+/CD8+in the treatment group were higher than those in the control group(P<0.05).After treatment,the serum levels of NSE,CYFRA21-1,and TSGF in both groups were significantly decreased(P<0.05),and the serum tumor marker levels in the treatment group were lower than those in the control group(P<0.05).Conclusion Pingxiao Capsules combined with Carrilizumab for injection can improve the health status and quality of life of patients with non-small cell lung cancer,improve immune function and reduce the level of tumor markers.
Pingxiao CapsulesCarrilizumab for injectionnon-small cell lung cancerKPS scoreQLQ-C30 scoreCD4CD4/CD8NSECYFRA21-1TSGF
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