蚌埠市第三人民医院妇产科门诊超说明书用药循证评价标准的应用分析
Application analysis of evidence-based evaluation criteria for off-label drug use in obstetrics and gynecology outpatient department of The Third the People's Hospital of Bengbu
张冠军 1程军 1司福国 1汪龙 1韩一萱1
作者信息
- 1. 蚌埠市第三人民医院 药学部,安徽 蚌埠 233000
- 折叠
摘要
目的 分析蚌埠市第三人民医院妇产科门诊超说明书用药情况,为促进合理用药提供参考.方法 通过合理用药软件随机等间距抽取 2022 年 4 月 1 日至 2024 年 3 月 31 日蚌埠市第三人民医院妇产科门诊处方 7 200 张,筛选出超说明书用药的处方,并基于循证医学证据对超说明用药处方进行合理性评价和分析.结果 随机抽取的 7 200 张妇产科门诊处方,超说明书用药的处方 364 张,超说明书用药处方占比为 5.06%,共涉及甲硝唑片、米索前列醇片等在内的 12 种药品,其中超给药途径处方为 241 张,占比66.21%,超适应证处方105 张,占比 28.84%,超剂量处方18 张,占比4.95%.226 张处方超说明书用药无高级别循证医学证据支持,判定为不合理处方,占比 62.09%.结论 蚌埠市第三人民医院妇产科门诊处方存在超说明书用药的现象,临床确需超说明书用药时应充分权衡利弊,建立相应的超说明书用药管理制度与流程,尽量规避医疗风险,保证临床用药安全.
Abstract
Objective To analyze the situation of off-label drug use in obstetrics and gynecology outpatient of The Third the People's Hospital of Bengbu,to provide reference for promoting rational drug use.Methods Through the rational drug use software,7 200 prescriptions of the obstetrics and gynecology outpatient department of The Third People's Hospital Bengbu from April 1,2022 to March 31,2024 were randomly selected at equal intervals,and the prescriptions of off-label drug use were screened out,and the rationality of the prescriptions of off-label drug use was evaluated and analyzed based on evidence-based medical evidence.Results Among the 7 200 prescriptions randomly selected in obstetrics and gynecology outpatient clinics,364 were off-label drug use,accounting for 5.06%,involving a total of 12 kinds of drugs,including Metronidazole Tablets,Misoprostol Tablets,among which Among them,there were 241 prescriptions of over-dose route,accounting for 66.21%,105 prescriptions of over-indication,accounting for 28.84%,and 18 prescriptions of over-dose,accounting for 4.95%.226(62.09%)prescriptions of off-label drug use were not supported by high-level evidence-based medical evidence,and were judged as unreasonable prescriptions.Conclusion The phenomenon of off-label drug use exists in the obstetrics and gynecology outpatient prescriptions of The Third People's Hospital Bengbu.When off-label drug use is really needed in clinic,the pros and cons should be fully weighed,and corresponding off-label drug use management system and process should be established to avoid medical risks as far as possible and ensure clinical drug safety.
关键词
妇产科/超说明书用药/用药安全/甲硝唑片/米索前列醇片Key words
obstetrics and gynecology/off-label drug use/drug safety/Metronidazole Tablets/Misoprostol Tablets引用本文复制引用
出版年
2024
NETL
NSTL
万方数据