萜类化合物调控信号通路改善肺纤维化的研究进展
Research progress on terpenoids regulating signaling pathway to improve pulmonary fibrosis
甘仕虎 1杨善军 2王玥2
作者信息
- 1. 黑龙江中医药大学,黑龙江 哈尔滨 150006
- 2. 黑龙江中医药大学附属第二医院,黑龙江 哈尔滨 150001
- 折叠
摘要
肺纤维化是呼吸系统疾病中常见的慢性、间质性肺疾病.目前治疗肺纤维化以肺移植治疗、抗肺纤维化药物治疗为主.萜类化合物具有显著的改善肺纤维化的作用,其作用机制分别为调控转化生长因子-β/Smad、核因子-κB、核因子E2 相关因子 2、信号转导和转录激活因子 6、蛋白激酶B信号通路.归纳了萜类化合物调控信号通路改善肺纤维化的研究进展,以期临床对肺纤维化治疗提供有效的药物治疗思路.
Abstract
Pulmonary fibrosis is a common chronic and interstitial lung disease in respiratory system diseases.At present,the main treatments for pulmonary fibrosis are lung transplantation and drug therapy.Terpenoids have significant effect on improving pulmonary fibrosis,and their mechanisms of action are to regulate transforming growth factor-β/Smad(TGF-β/Smad),nuclear factor-κB(NF-κB),nuclear factor E2 related factor 2(Nrf2),signal transduction and transcriptional activation factor 6(STAT6),and protein kinase B(Akt)signaling pathway.This article summarizes the research progress on terpenoids regulating signaling pathways to improve pulmonary fibrosis,in order to provide effective drug treatment ideas for the clinical treatment of pulmonary fibrosis.
关键词
萜类化合物/肺纤维化/转化生长因子-β/Smad信号通路/核因子-κB信号通路/核因子E2相关因子2信号通路/信号转导和转录激活因子6信号通路/蛋白激酶B信号通路Key words
terpenoids/pulmonary fibrosis/transforming growth factor-β/Smad signaling pathway/nuclear factor κB signaling pathway/nuclear factor E2 related factor 2 signaling pathway/signal transduction and transcription activator 6 signaling pathway/protein kinase B引用本文复制引用
基金项目
黑龙江省自然科学基金项目(LH2020H100)
黑龙江省中医局中医药科研课题(ZHY2022-182)
哈尔滨市科技创新人才研究专项(2017RAQXJ189)
出版年
2024
NETL
NSTL
万方数据