Nerolidol is a natural sesquiterpene product with various pharmacological effects,and has good protective properties against nerve damage.The neuroprotective mechanism of nerolidol includes inhibiting oxidative stress,suppressing inflammatory response,improving neurotransmitters and preventing cell apoptosis,and regulating cytochrome P450 enzyme activity.This article summarizes the research progress on neuroprotective mechanism of nerolidol,providing a theoretical basis for its application in treatment of neurological diseases.