多指标成分测定结合化学计量学评价金花消痤丸质量
Quality evaluation of Jinhua Xiaocuo Pills by multi-index component analysis combined with chemometrics
王军 1史学礼 1王蓉 2郑利梅 1倪恒雨 3董恒岳1
作者信息
- 1. 亳州市食品药品检验中心,安徽 亳州 236800
- 2. 亳州职业技术学院,安徽亳州 236800
- 3. 淮南市食品药品检验中心,安徽 淮南 232000
- 折叠
摘要
目的 采用多指标成分测定结合化学计量学评价金花消痤丸的质量.方法 采用HPLC法测定10批金花消痤丸中栀子苷、盐酸小檗碱、黄芩苷、汉黄芩苷、黄芩素、汉黄芩素、芦荟大黄素、大黄素、大黄酚、大黄素甲醚,结合聚类分析、主成分分析、正交偏最小二乘法-判别分析评价不同批次金花消痤丸样品的质量差异.结果 10批金花消痤丸样品分为两类,样品间差异不大,较类似.4个主成分的累计方差贡献率达到了83.201％.结论 方法简单快捷,重复性好,精密度优良,结果较准确,可以为金花消痤丸的质量控制提供参考.
Abstract
Objective To evaluate the quality of Jinhua Xiaocuo Pills by multi-index component analysis combined with chemometrics. Methods HPLC method was used to determine contents of geniposide,berberine hydrochloride,baicalin,wogonoside,baicalein,wogonin,aloe emodin,emodin,chrysophanol,and emodin-3-methyl ether in 10 batches of Jinhua Xiaocuo Pills. Cluster analysis,principal component analysis,and orthogonal partial least squares discriminant analysis were used to evaluate the quality differences of different batches of Jinhua Xiaocuo Pills. Results The 10 batches of Jinhua Xiaocuo Pills were divided into two categories,with little difference between the samples,and were relatively similar. The total cumulative contribution value of the four principal components reached 83.201％. Conclusion This method is simple,fast,has good repeatability,excellent precision,and accurate results,which can provide reference for the quality control of Jinhua Xiaocuo Pills.
关键词
金花消痤丸/栀子苷/盐酸小檗碱/黄芩苷/汉黄芩苷/黄芩素/汉黄芩素/芦荟大黄素/大黄素/大黄酚/大黄素甲醚/聚类分析/主成分分析/正交偏最小二乘法-判别分析Key words
Jinhua Xiaocuo Pills/geniposide/berberine hydrochloride/baicalin/wogonoside/baicalein/wogonin/aloe emodin/emodin/chrysophanol/emodin-3-methyl ether/cluster analysis/principal component analysis/orthogonal partial least squares discriminant analysis引用本文复制引用
基金项目
安徽省教育厅高校优秀人才支持计划(gxyq2021277)
出版年
2024
NETL
NSTL
万方数据