首页|多指标成分测定结合化学计量学评价金花消痤丸质量

多指标成分测定结合化学计量学评价金花消痤丸质量

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
目的 采用多指标成分测定结合化学计量学评价金花消痤丸的质量。方法 采用HPLC法测定10批金花消痤丸中栀子苷、盐酸小檗碱、黄芩苷、汉黄芩苷、黄芩素、汉黄芩素、芦荟大黄素、大黄素、大黄酚、大黄素甲醚，结合聚类分析、主成分分析、正交偏最小二乘法-判别分析评价不同批次金花消痤丸样品的质量差异。结果 10批金花消痤丸样品分为两类，样品间差异不大，较类似。4个主成分的累计方差贡献率达到了83。201％。结论 方法简单快捷，重复性好，精密度优良，结果较准确，可以为金花消痤丸的质量控制提供参考。
Quality evaluation of Jinhua Xiaocuo Pills by multi-index component analysis combined with chemometrics
Objective To evaluate the quality of Jinhua Xiaocuo Pills by multi-index component analysis combined with chemometrics. Methods HPLC method was used to determine contents of geniposide,berberine hydrochloride,baicalin,wogonoside,baicalein,wogonin,aloe emodin,emodin,chrysophanol,and emodin-3-methyl ether in 10 batches of Jinhua Xiaocuo Pills. Cluster analysis,principal component analysis,and orthogonal partial least squares discriminant analysis were used to evaluate the quality differences of different batches of Jinhua Xiaocuo Pills. Results The 10 batches of Jinhua Xiaocuo Pills were divided into two categories,with little difference between the samples,and were relatively similar. The total cumulative contribution value of the four principal components reached 83.201％. Conclusion This method is simple,fast,has good repeatability,excellent precision,and accurate results,which can provide reference for the quality control of Jinhua Xiaocuo Pills.

Jinhua Xiaocuo Pillsgeniposideberberine hydrochloridebaicalinwogonosidebaicaleinwogoninaloe emodinemodinchrysophanolemodin-3-methyl ethercluster analysisprincipal component analysisorthogonal partial least squares discriminant analysis

王军、史学礼、王蓉、郑利梅、倪恒雨、董恒岳

展开 >

亳州市食品药品检验中心,安徽 亳州 236800

亳州职业技术学院,安徽亳州 236800

淮南市食品药品检验中心,安徽 淮南 232000

金花消痤丸 栀子苷 盐酸小檗碱 黄芩苷 汉黄芩苷 黄芩素 汉黄芩素 芦荟大黄素 大黄素 大黄酚 大黄素甲醚 聚类分析 主成分分析 正交偏最小二乘法-判别分析

安徽省教育厅高校优秀人才支持计划

gxyq2021277

2024

10.7501/j.issn.1674-5515.2024.09.009

现代药物与临床
天津药物研究院,中国药学会

现代药物与临床

CSTPCD
影响因子：1.179
ISSN：1674-5515
年,卷(期)：2024.39(9)
  • 6