Clinical study on butylphthalide sequential therapy combined with alteplase in treatment of acute cerebral infarction
Objective To analyze the effect of butylphthalide sequential therapy combined with alteplase in treatment of acute cerebral infarction. Methods Patients (80 cases) with acute cerebral infarction in Jiading Branch of Shanghai General Hospital from January 2021 to December 2023 were divided into control and treatment group by random draw,and each group had 40 cases. Patients in the control group were iv administered with Alteplase for injection,0.9 mg/kg,first,10％ of the total dose was injected intravenously,and the bolus was completed within 60 s,and the rest medicine was injected intravenously within 1 h. Patients in the treatment group were iv administered with Butylphthalide Injection on the basis of the control group for 2 weeks,after the condition stabilized,they were po administered with Butylphthalide Soft Capsules,0.2 g/time,three times daily. Patients in two groups were treated for 3 weeks. After treatment,the clinical evaluations were evaluated,the hemorheological function,coagulation function,neurological deficits,cognitive function,inflammatory response,neuroimaging function in two groups before and after treatment were compared. Results After treatment,the clinical effective rate in the treatment group was significantly higher than that in the control group (97.50％ vs 80.00％,P<0.05). After treatment,the platelet inhibition rate,APTT,PT,and rADC were significantly increased in two groups,while the platelet adhesion rate,whole blood viscosity,red blood cell sedimentation rate,FIB,PLT,white blood cell count,neutrophil ratio,CRP,and infarction volume were significantly decreased (P<0.05),and the levels of these indicators in the treatment group were significantly better than those in the control group after treatment (P<0.05). After treatment,the NIHSS scores in two groups were significantly lower than those before treatment,while the MMSE scores were significantly higher than those before treatment (P<0.05). After treatment,the NIHSS and MMSE scores in the treatment group were significantly better than those of the control group (P<0.05). Conclusions The combination of butylphthalide sequential therapy with alteplase thrombolysis can improve neurological function,hemodynamics and coagulation status in patients with acute cerebral infarction,promote the recovery of cognitive function,and reduce inflammatory response.
Alteplase for injectionButylphthalide Soft Capsulessequential therapyacute cerebral infarctionhemrheologycoagulation indicatorsneurological deficits
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