Clinical study on Xintong Granules combined with sacubactril valsartan in treatment of chronic heart failure with ejection fraction preservation
Objective To investigate the effect of Xintong Granules combined with Sacubitril Valsartan Sodium Tablets in treatment of chronic heart failure with ejection fraction preservation. Methods A total of 80 patients with chronic heart failure with ejection fraction preservation who were treated in Enyang District People's Hospital of Bazhong from March 2021 to February 2024 were selected and divided into control group and treatment group according to computer random arrangement method,with 40 cases in each group. Patients in the control group took Sacubitril Valsartan Sodium Tablets orally,the initial dose was 1 tablet/time,2 times daily,the dose was gradually increased according to individual tolerance,and the maintenance dose was 4 tablets/time,2 times daily. Patients in the treatment group were given Xintong Granules orally on the basis of the control group,2 bags/time,3 times daily. Patients of two groups were treated for 2 months. The clinical efficacy,disease status,cardiac function index,and serum index of the two groups were compared. Results After 2 months of treatment,the total effective rate in the treatment group (95.00％) was higher than 77.50％ in the control group,and the difference between groups was significant (P<0.05). LEE score of the two groups was significantly decreased after treatment (P<0.05),and LEE score in the treatment group was higher than that of the control group (P<0.05). After treatment,LVEF of two groups was higher than that before treatment,but E/e' and IVRT of two groups were lower than that before treatment (P<0.05). VEF in treatment group was higher than that in control group,but E/e' and IVRT were lower than that in control group (P<0.05). The levels of APN,galectin 3,sST2,and NT-proBNP in two groups were lower than those before treatment (P<0.05). The levels of APN,galectin 3,sST2,and NT-proBNP in the treatment group were lower than those in the control group (P<0.05). Conclusion Xintong Granules combined with Sacubitril Valsartan Sodium Tablets can improve the efficacy of chronic heart failure with ejection fraction preservation,control the progression of disease,improve heart function,and reduce myocardial damage.
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