Clinical study on compound pholcodine combined with doxycycline in treatment of macrolide-resistant Mycoplasma pneumonia in children
Objective Exploring the therapeutic effect of compound pholcodine combined with doxycycline in treatment of macrolide-resistant Mycoplasma pneumonia. Methods Children (82 cases) with macrolide-resistant Mycoplasma pneumonia in Wuwei People's Hospital from April 2022 to April 2024 were divided into control (41 cases) and treatment (41 cases) group based on different treatments. Children in the control group were po administered with Doxycycline Hyclate Tablets,children weighing ≤ 45 kg taken 2.2 mg/kg every 12 h,and children weighing>45 kg taken 100 mg every 12 h. Children in the treatment group were po administered with Compound Pholcodine Oral Solution on the basis of the control group,10 mL/time,three times daily. Children in two groups were treated for 7 d. After treatment,the clinical evaluations were evaluated,the disappearance time of clinical main symptoms,the scores of TCM syndrome and PCIS,the serum LDH,CRP,and D-D levels in two groups before and after treatment were compared. Results After treatment,the total clinical effective rates in the control group and the treatment group were 80.49％ and 95.12％,respectively,and the difference between the two groups was statistically significant (P<0.05). After treatment,the disappearance time of fever,cough,wheezing,and pulmonary rales in the treatment group was significantly shorter than that in the control group (P<0.05). After treatment,the TCM syndrome scores of children in two groups were significantly decreased,while the PCIS scores were significantly increased (P<0.05),and the scores in the treatment group were significantly better than those in the control group (P<0.05). After treatment,the serum LDH,CRP,and D-D levels of patients in two groups were significantly reduced (P<0.05),and all indicators in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion The combination of compound forcodeine and doxycycline has a significant therapeutic effect on children with macrolide resistant Mycoplasma pneumoniae. It can not only significantly improve the disappearance time of clinical symptoms and traditional Chinese medicine syndrome scores,but also promote the recovery of serological indicators.
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