Clinical study on Lianhua Qingwen Granules combined with erythromycin lactobionate in treatment of mycoplasma pneumonia in children
Objective To explore the therapeutic effect of Lianhua Qingwen Granules combined with erythromycin lactobionate in treatment of mycoplasma pneumonia in children. Methods Children (90 cases) with mycoplasma pneumonia in West Anhui Health Vocational College from January 2022 to January 2023 were divided into control (45 cases) and treatment (45 cases) group based on different treatments. Children in the control group were iv administered with Erythromycin Lactobionate for injection,30 mg/kg added into normal saline 250 mL,once daily. Children in the treatment group were po administered with Lianhua Qingwen Granules on the basis of the control group,6 g/time,three times daily. Children in two groups were treated for 10 d. After treatment,the clinical evaluations were evaluated,the disappearance time of clinical symptoms,the scores of TCM syndrome and pulmonary imaging,the levels of serum sTLR4,IL-17 and D-D in two groups before and after treatment were compared. Results After treatment,the total clinical effective rates in the control group and the treatment group were 84.44％ and 95.56％ respectively (P<0.05). After treatment,the improvement time for fever,cough,muscle soreness and moist lung rales in the treatment group was significantly shorter than that in the control group (P<0.05). After treatment,the TCM syndrome scores and lung imaging scores of children in two groups were significantly reduced (P<0.05),and the scores in the treatment group were significantly lower than those in the control group (P<0.05). After treatment,the serum sTLR4,IL-17 and D-D levels of children in two groups were significantly reduced (P<0.05),and which were significantly lower in the treatment group than those in the control group (P<0.05). Conclusion The combination of Lianhua Qingwen Granules and Erythromycin Lactobionate for injection has a significant therapeutic effect on the treatment of Mycoplasma pneumoniae lobar pneumonia in children. It can not only significantly improve the clinical symptoms of children and accelerate the absorption of inflammatory lesions,but also promote the recovery of serological indicators without increasing adverse reactions.
Lianhua Qingwen GranulesErythromycin Lactobionate for injectionMycoplasma pneumoniaelobar pneumoniaTCM syndrome scoresTLR4D-D
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