Clinical study on Xiao'er Jingxing Zhike Granules combined with ribavirin in treatment of acute upper respiratory tract infection in children
Objective To explore the clinical effect of Xiao'er Jingxing Zhike Granules combined with ribavirin in treatment of acute upper respiratory tract infection in children. Methods Children (84 cases) with acute upper respiratory tract infection in Chengde Central Hospital from May 2022 to May 2024 were divided into control (42 cases) and treatment (42 cases) group based on different treatments. Children in the control group were po administered with Ribavirin Granules,50 mg/time,twice daily. Children in the treatment group were po administered with Xiao'er Jingxing Zhike Granules on the basis of the control group,0.5 bag/time for 3-5 years old children,1 bag/time for more than 6 years old children,three times daily. Children in two groups were treated for 7 d. After treatment,the clinical evaluations were evaluated,the symptom disappearance time,CSHQ scores,the serological levels of SAA,ADA,PA and IFN-γ in two groups before and after treatment were compared. Results After treatment,the effective rate in the treatment group was 95.24％,which was significantly higher than that in the control group (78.57％,P<0.05). After treatment,compared with the control group,the disappearance time for symptoms such as fever,headache,sore throat,and nasal congestion in the treatment group was significantly shortened (P<0.05). After treatment,the sleep quality scores in two groups were significantly decreased (P<0.05),and the CSHQ scores were decreased more significantly in the treatment group (P<0.05). After treatment,the levels of SAA and ADA were significantly decreased intwo groups,while the levels of PA and IFN-γ were significantly increased (P<0.05). The levels of SAA,ADA,PA and IFN-γ in the treatment group were significantly better than those in the control group (P<0.05). Conclusion The coordinated treatment of ribavirin and Xiao'er Jingxing Zhike Granules can significantly improve the symptoms and signs of respiratory infection in children,weaken local inflammatory reactions,enhance the body's immunity,and effectively improve the sleep quality of children.
NETL
NSTL
万方数据
